Molecular Barriers to Zoonotic Transmission of Prions

The risks posed to human health by individual animal prion diseases cannot be determined a priori and are difficult to address empirically.The fundamental event in prion disease pathogenesis is thought to be the seeded conversion of normal prion protein to its pathologic isoform.We used a rapid molecular conversion assay (protein misfolding cyclic

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Platelet function in brown bear (Ursus arctos) compared to man

Abstract Background Information on hemostasis and platelet function in brown bear (Ursus arctos) is of importance for understanding the physiological, protective changes during hibernation.Objective The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in heal

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Repression by the H-NS/YmoA histone-like protein complex enables IscR dependent regulation of the Yersinia T3SS.

The type III secretion system (T3SS) is an appendage used by many bacterial pathogens, such as pathogenic Yersinia, to subvert host defenses.However, because the T3SS is energetically costly and immunogenic, it must be tightly regulated in response to environmental cues to enable survival in the host.Here we show that expression of the Yersinia Ysc

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